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KMID : 0602819950010010055
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Korean Journal of Bronchoesophagology
1995 Volume.1 No. 1 p.55 ~ p.63
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Experimental Study of the Role of Gastric Acid and Pepsin in Laryngotracheal Stenosis
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Abstract
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Gastroesophageal refulx is thought to be an important etiology of the various upper
aerodigestive tract disease. To investigate the role of gastric acid and pepsin as an etiologic
factor of laryngotracheal stenosis, and the difference of injury by synthetic gastric juice
between in ciliated respiratory epithelium and in squamous epithelium, experimental study was
carried out using rabbits. Mucociliary transport affected by synthetic gastric juice was also
studied in dogs. Synthetic gastric juice of low pH caused serious damage and impairment of
mucociliary transport in the epithelium of the larynx and trachea. Gastric acid played major
role in the mucosal damage. Squamous epithelium of vocal folds and pharynx was more
resistant to synthetic gastric juice than respiratory epitheium. In conclusion, gastroesophageal
reflux may be an etiologic factor in the developement of laryngotracheal stenosis, so the
adequate management is necessory in patients of laryngotracheal stenosis.
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